Orchestrate an exhaustive, multi-database systematic literature review — taxonomy to tiered reference library to synthesis. Use when the ask is a comprehensive/exhaustive review of a disease or topic (not a single "what's the seminal paper" lookup). Layers on the base literature-review skill: query-matrix design, multi-DB retrieval (PubMed + OpenAlex + citation-graph), DOI dedup, LLM relevance screen, Tier-1/2/3 evidence rubric with topical-specificity guardrail, and the evidence-map figure. Disease-agnostic via a swappable taxonomy.