Use when selecting, starting, or resuming an evidence-gated research route for a top computer-science venue or Nature-family journal; source-grounded paper reading, AI-for-biology data feasibility, scoop checks, venue fit, baseline headroom, frozen protocols, controlled iterations, claim locking, negative-result handling, preparing a full working manuscript with figures, or curating a reproducible public code release. The workflow completes its local research-to-manuscript scope without another skill; compute, locked-test access, canonical mutation and external writes require their own authorization.