CTD 2.7.3.4 and 2.7.4 exposure-safety review

Reviews CTD 2.7.3.4 and 2.7.4 exposure-safety content against the analyses behind it. It traces every stated relationship to its analysis in both directions, so an omitted analysis is caught as well as an unsupported claim, treats a negative statement as a claim requiring evidence rather than an absence of one, and reports underpowered negatives separately from supported negatives because the two read identically and mean the opposite. It also checks exposure metric and analyte coherence against the clinical pharmacology summary. Use it for draft or filed exposure-safety sections, or to prepare an agency response. Example: "Please draft or filed exposure-safety sections."…