Reviews stated exposure safety margins — the ratio between a nonclinical no-observed-adverse-effect exposure and a clinical exposure — for whether each margin's basis is stated, its two sides are comparable, and its arithmetic reconciles. Use this skill when someone asks to review, QC, or trace a safety margin, a DILI or organ-toxicity exposure margin, or an exposure-based safety statement — for example "check the hepatic margin in the IB against the tox report" or "does every stated margin say which exposure metric and species it uses". Do not use to decide whether a margin is adequate, to set an exposure cap or stopping rule, to select a dose, to interpret a safety sign…
