Use when a plugin or theme makes outbound HTTP requests with the WordPress HTTP API - wp_remote_get, wp_remote_post, wp_remote_request - especially when any part of the URL comes from user input, options, or webhooks. Uses wp_safe_remote_* with wp_http_validate_url, allowlists hosts, blocks internal and metadata addresses, and checks is_wp_error plus the response code. Prevents server-side request forgery.